- •Foreword
- •Preface
- •Contents
- •About the Editors
- •Contributors
- •1: Tracheobronchial Anatomy
- •Trachea
- •Introduction
- •External Morphology
- •Internal Morphology
- •Mucous Layer
- •Blood Supply
- •Anatomo-Clinical Relationships
- •Bronchi
- •Main Bronchi
- •Bronchial Division
- •Left Main Bronchus (LMB)
- •Right Main Bronchus (RMB)
- •Blood Supply
- •References
- •2: Flexible Bronchoscopy
- •Introduction
- •History
- •Description
- •Indications and Contraindications
- •Absolute Contraindications
- •Procedure Preparation
- •Technique of FB Procedure
- •Complications of FB Procedure
- •Basic Diagnostic Procedures
- •Bronchoalveolar Lavage (BAL)
- •Transbronchial Lung Biopsy (TBLB)
- •Transbronchial Needle Aspiration (TBNA)
- •Bronchial Brushings
- •Advanced Diagnostic Bronchoscopy
- •EBUS-TBNA
- •Ultrathin Bronchoscopy
- •Transbronchial Lung Cryobiobsy (TBLC)
- •Therapeutic Procedures Via FB
- •LASER Bronchoscopy
- •Electrocautery
- •Argon Plasma Coagulation (APC)
- •Cryotherapy
- •Photodynamic Therapy
- •Airway Stent Placement
- •Endobronchial Valve Placement
- •Conclusion
- •References
- •History and Historical Perspective
- •Indications and Contraindications
- •Procedure Description
- •Procedure Planning
- •Target Approximation
- •Sampling
- •Complications
- •Future Directions
- •Summary and Recommendations
- •References
- •4: Rigid Broncoscopy
- •Innovations
- •Ancillary Equipment
- •Rigid Bronchoscopy Applications
- •Laser Bronchoscopy
- •Tracheobronchial Prosthesis
- •Transbronchial Needle Aspiration (TBNA)
- •Rigid Bronchoscope in Other Treatments for Bronchial Obstruction
- •Mechanical Debridement
- •Pediatric Rigid Bronchoscopy
- •Tracheobronchial Dilatation
- •Foreign Bodies Removal
- •Other Indications
- •Complications
- •The Procedure
- •Some Conclusions
- •References
- •History and Historical Perspective
- •Indications and Contraindications
- •Preprocedural Evaluation and Preparation
- •Physical Examination
- •Procedure-Related Indications
- •Application of the Technique
- •Topical Anesthesia
- •Anesthesia of the Nasal Mucosa and Nasopharynx
- •Anesthesia of the Mouth and Oropharynx
- •Superior Laryngeal Nerve Block
- •Recurrent Laryngeal Nerve Block (RLN)
- •Conscious Sedation
- •Monitored Anesthesia Care (MAC)
- •General Anesthesia
- •Monitoring the Depth of Anesthesia
- •Interventional Bronchoscopy Suites
- •Airway Devices
- •Laryngeal Mask Airway (LMA)
- •Endotracheal Tube (ETT)
- •Rigid Bronchoscope
- •Modes of Ventilation
- •Spontaneous Ventilation
- •Assisted Ventilation
- •Noninvasive Positive Pressure Ventilation (NIV)
- •Positive Pressure Controlled Mechanical Ventilation
- •Jet Ventilation
- •Electronic Mechanical Jet Ventilation
- •Postprocedure Care
- •Special Consideration
- •Anesthesia for Peripheral Diagnostic and Therapeutic Bronchoscopy
- •Anesthesia for Interventional Bronchoscopic Procedures During the COVID-19 Pandemic
- •Summary and Recommendations
- •Conclusion
- •References
- •Background
- •Curricular Structure and Delivery
- •What Is a Bronchoscopy Curriculum?
- •Tradition, Teaching Styles, and Beliefs
- •Using Assessment Tools to Guide the Educational Process
- •The Ethics of Teaching
- •When Learners Teach: The Journey from Novice to Mastery and Back Again
- •The Future Is Now
- •References
- •Interventional Procedure
- •Assessment of Flow–Volume Curve
- •Dyspnea
- •Analysis of Pressure–Pressure Curve
- •Conclusions
- •References
- •Introduction
- •Adaptations of the IP Department
- •Environmental Control
- •Personal Protective Equipment
- •Procedure Performance
- •Bronchoscopy in Intubated Patients
- •Other Procedures in IP Unit
- •References
- •Introduction
- •Safety
- •Patient Safety
- •Provider Safety
- •Patient Selection and Screening
- •Lung Cancer Diagnosis and Staging
- •Inpatients
- •COVID-19 Clearance
- •COVID Clearance: A Role for Bronchoscopy
- •Long COVID: A Role for Bronchoscopy
- •Preparing for the Next Pandemic
- •References
- •Historical Perspective
- •Indications and Contraindications
- •Evidence-Based Review
- •Summary and Recommendations
- •References
- •Introduction
- •Clinical Presentation
- •Diagnosis
- •Treatment
- •History and Historical Perspectives
- •Indications and Contraindications
- •Benign and Malignant Tumors
- •Tumors with Uncertain Prognosis
- •Application of the Technique
- •Evidence Based Review
- •Summary and Recommendations
- •References
- •12: Cryotherapy and Cryospray
- •Introduction
- •Historical Perspective
- •Equipment
- •Cryoadhesion
- •Indications
- •Cryorecanalization
- •Cryoadhesion and Foreign Body Removal
- •Cryoadhesion and Mucus Plugs/Blood Clot Retrieval
- •Endobronchial Cryobiopsy
- •Transbronchial Cryobiopsy for Lung Cancer
- •Safety Concerns and Contraindications
- •Cryoablation
- •Indications
- •Evidence
- •Safety Concerns and Contraindications
- •Cryospray
- •Indications
- •Evidence
- •Safety Concerns and Contraindications
- •Advantages of Cryotherapy
- •Limitations
- •Future Research Directions
- •References
- •13: Brachytherapy
- •History and Historical Perspective
- •Indications and Contraindications
- •Application of the Technique
- •Evidence-Based Review
- •Adjuvant Treatment
- •Palliative Treatment
- •Complications
- •Summary and Recommendations
- •References
- •14: Photodynamic Therapy
- •Introduction
- •Photosensitizers
- •First-Generation Photosensitizers
- •M-Tetrahidroxofenil Cloro (mTHPC) (Foscan®)
- •PDT Reaction
- •Tumor Damage Process
- •Procedure
- •Indications
- •Curative PDT Indications
- •Palliative PDT Indications
- •Contraindications
- •Rationale for Use in Early-Stage Lung Cancer
- •Rationale
- •PDT in Combination with Other Techniques for Advanced-Stage Non-small Cell Lung Cancer
- •Commentary
- •Complementary Endoscopic Methods for PDT Applications
- •New Perspectives
- •Other PDT Applications
- •Conclusions
- •References
- •15: Benign Airways Stenosis
- •Etiology
- •Congenital Tracheal Stenosis
- •Iatrogenic
- •Infectious
- •Idiopathic Tracheal Stenosis
- •Distal Bronchial Stenosis
- •Diagnosis Methods
- •Patient History
- •Imaging Techniques
- •Bronchoscopy
- •Pulmonary Function Test
- •Treatment
- •Endoscopic Treatment
- •Dilatation
- •Laser Therapy
- •Stents
- •How to Proceed
- •Stent Placement
- •Placing a Montgomery T Tube
- •The Rule of Twos for Benign Tracheal Stenosis (Fig. 15.23)
- •Surgery
- •Summary and Recommendations
- •References
- •16: Endobronchial Prostheses
- •Introduction
- •Indications
- •Extrinsic Compression
- •Intraluminal Obstruction
- •Stump Fistulas
- •Esophago-respiratory Fistulas (ERF)
- •Expiratory Central Airway Collapse
- •Physiologic Rationale for Airway Stent Insertion
- •Stent Selection Criteria
- •Stent-Related Complications
- •Granulation Tissue
- •Stent Fracture
- •Migration
- •Contraindications
- •Follow-Up and Patient Education
- •References
- •Introduction
- •Overdiagnosis
- •False Positives
- •Radiation
- •Risk of Complications
- •Lung Cancer Screening Around the World
- •Incidental Lung Nodules
- •Management of Lung Nodules
- •References
- •Introduction
- •Minimally Invasive Procedures
- •Mediastinoscopy
- •CT-Guided Transthoracic Biopsy
- •Fluoroscopy-Guided Transthoracic Biopsies
- •US-Guided Transthoracic Biopsy
- •Thoracentesis and Pleural Biopsy
- •Thoracentesis
- •Pleural Biopsy
- •Surgical or Medical Thoracoscopy
- •Image-Guided Pleural Biopsy
- •Closed Pleural Biopsy
- •Image-Guided Biopsies for Extrathoracic Metastases
- •Tissue Acquisition, Handling and Processing
- •Implications of Tissue Acquisition
- •Guideline Recommendations for Tissue Acquisition in Mediastinal Staging
- •Methods to Overcome Challenges in Tissue Acquisition and Genotyping
- •Rapid on-Site Evaluation (ROSE)
- •Sensitive Genotyping Assays
- •Liquid Biopsy
- •Summary, Recommendations and Highlights
- •References
- •History
- •Data Source and Methodology
- •Tumor Size
- •Involvement of the Main Bronchus
- •Atelectasis/Pneumonitis
- •Nodal Staging
- •Proposal for the Revision of Stage Groupings
- •Small Cell Lung Cancer (SCLC)
- •Discussion
- •Methodology
- •T Descriptors
- •N Descriptors
- •M Descriptors
- •Summary
- •References
- •Introduction
- •Historical Perspective
- •Fluoroscopy
- •Radial EBUS Mini Probe (rEBUS)
- •Ultrasound Bronchoscope (EBUS)
- •Virtual Bronchoscopy
- •Trans-Parenchymal Access
- •Cone Beam CT (CBCT)
- •Lung Vision
- •Sampling Instruments
- •Conclusions
- •References
- •History and Historical Perspective
- •Narrow Band Imaging (NBI)
- •Dual Red Imaging (DRI)
- •Endobronchial Ultrasound (EBUS)
- •Optical Coherence Tomography (OCT)
- •Indications and Contraindications
- •Confocal Laser Endomicroscopy and Endocytoscopy
- •Raman Spectrophotometry
- •Application of the Technique
- •Supplemental Technology for Diagnostic Bronchoscopy
- •Evidence-Based Review
- •Summary and Recommendations, Highlight of the Developments During the Last Three Years (2013 on)
- •References
- •Introduction
- •History and Historical Perspective
- •Endoscopic AF-OCT System
- •Preclinical Studies
- •Clinical Studies
- •Lung Cancer
- •Asthma
- •Airway and Lumen Calibration
- •Obstructive Sleep Apnea
- •Future Applications
- •Summary
- •References
- •23: Endobronchial Ultrasound
- •History and Historical Perspective
- •Equipment
- •Technique
- •Indication, Application, and Evidence
- •Convex Probe Ultrasound
- •Equipment
- •Technique
- •Indication, Application, and Evidence
- •CP-EBUS for Malignant Mediastinal or Hilar Adenopathy
- •CP-EBUS for the Staging of Non-small Cell Lung Cancer
- •CP-EBUS for Restaging NSCLC After Neoadjuvant Chemotherapy
- •Complications
- •Summary
- •References
- •Introduction
- •What Is Electromagnetic Navigation?
- •SuperDimension Navigation System (EMN-SD)
- •Computerized Tomography
- •Computer Interphase
- •The Edge Catheter: Extended Working Channel (EWC)
- •Procedural Steps
- •Planning
- •Detecting Anatomical Landmarks
- •Pathway Planning
- •Saving the Plan and Exiting
- •Registration
- •Real-Time Navigation
- •SPiN System Veran Medical Technologies (EMN-VM)
- •Procedure
- •Planning
- •Navigation
- •Biopsy
- •Complications
- •Limitations
- •Summary
- •References
- •Introduction
- •Image Acquisition
- •Hardware
- •Practical Considerations
- •Radiation Dose
- •Mobile CT Studies
- •Future Directions
- •Conclusion
- •References
- •26: Robotic Assisted Bronchoscopy
- •Historical Perspective
- •Evidence-Based Review
- •Diagnostic Yield
- •Monarch RAB
- •Ion Endoluminal Robotic System
- •Summary
- •References
- •History and Historical Perspective
- •Indications and Contraindications
- •General
- •Application of the Technique
- •Preoperative Care
- •Patient’s Position and Operative Field
- •Incision and Initial Dissection
- •Palpation
- •Biopsy
- •Control of Haemostasis and Closure
- •Postoperative Care
- •Complications
- •Technical Variants
- •Extended Cervical Mediastinoscopy
- •Mediastinoscopic Biopsy of Scalene Lymph Nodes
- •Inferior Mediastinoscopy
- •Mediastino-Thoracoscopy
- •Video-Assisted Mediastinoscopic Lymphadenectomy
- •Transcervical Extended Mediastinal Lymphadenectomy
- •Evidence-Based Review
- •Summary and Recommendations
- •References
- •Introduction
- •Case 1
- •Adrenal and Hepatic Metastases
- •Brain
- •Bone
- •Case 1 Continued
- •Biomarkers
- •Case 1 Concluded
- •Case 2
- •Chest X-Ray
- •Computerized Tomography
- •Positive Emission Tomography
- •Magnetic Resonance Imaging
- •Endobronchial Ultrasound with Transbronchial Needle Aspiration
- •Transthoracic Needle Aspiration
- •Transbronchial Needle Aspiration
- •Endoscopic Ultrasound with Needle Aspiration
- •Combined EUS-FNA and EBUS-TBNA
- •Case 2 Concluded
- •Case 3
- •Standard Cervical Mediastinoscopy
- •Extended Cervical Mediastinoscopy
- •Anterior Mediastinoscopy
- •Video-Assisted Thoracic Surgery
- •Case 3 Concluded
- •Case 4
- •Summary
- •References
- •29: Pleural Anatomy
- •Pleural Embryonic Development
- •Pleural Histology
- •Cytological Characteristics
- •Mesothelial Cells Functions
- •Pleural Space Defense Mechanism
- •Pleura Macroscopic Anatomy
- •Visceral Pleura (Pleura Visceralis or Pulmonalis)
- •Parietal Pleura (Pleura Parietalis)
- •Costal Parietal Pleura (Costalis)
- •Pleural Cavity (Cavitas Thoracis)
- •Pleural Apex or Superior Pleural Sinus [12–15]
- •Anterior Costal-Phrenic Sinus or Cardio-Phrenic Sinus
- •Posterior Costal-Phrenic Sinus
- •Cost-Diaphragmatic Sinus or Lateral Cost-Phrenic Sinus
- •Fissures18
- •Pleural Vascularization
- •Parietal Pleura Lymphatic Drainage
- •Visceral Pleura Lymphatic Drainage
- •Pleural Innervation
- •References
- •30: Chest Ultrasound
- •Introduction
- •The Technique
- •The Normal Thorax
- •Chest Wall Pathology
- •Pleural Pathology
- •Pleural Thickening
- •Pneumothorax
- •Pulmonary Pathology
- •Extrathoracic Lymph Nodes
- •COVID and Chest Ultrasound
- •Conclusions
- •References
- •Introduction
- •History of Chest Tubes
- •Overview of Chest Tubes
- •Contraindications for Chest Tube Placement
- •Chest Tube Procedural Technique
- •Special Considerations
- •Pneumothorax
- •Empyema
- •Hemothorax
- •Chest Tube Size Considerations
- •Pleural Drainage Systems
- •History of and Introduction to Indwelling Pleural Catheters
- •Indications and Contraindications for IPC Placement
- •Special Considerations
- •Non-expandable Lung
- •Chylothorax
- •Pleurodesis
- •Follow-Up and IPC Removal
- •IPC-Related Complications and Management
- •Competency and Training
- •Summary
- •References
- •32: Empyema Thoracis
- •Historical Perspectives
- •Incidence
- •Epidemiology
- •Pathogenesis
- •Clinical Presentation
- •Radiologic Evaluation
- •Biochemical Analysis
- •Microbiology
- •Non-operative Management
- •Prognostication
- •Surgical Management
- •Survivorship
- •Summary and Recommendations
- •References
- •Evaluation
- •Initial Intervention
- •Pleural Interventions for Recurrent Symptomatic MPE
- •Especial Circumstances
- •References
- •34: Medical Thoracoscopy
- •Introduction
- •Diagnostic Indications for Medical Thoracoscopy
- •Lung Cancer
- •Mesothelioma
- •Other Tumors
- •Tuberculosis
- •Therapeutic Indications
- •Pleurodesis of Pneumothorax
- •Thoracoscopic Drainage
- •Drug Delivery
- •Procedural Safety and Contraindications
- •Equipment
- •Procedure
- •Pre-procedural Preparations and Considerations
- •Procedural Technique [32]
- •Medical Thoracoscopy Versus VATS
- •Conclusion
- •References
- •Historical Perspective
- •Indications and Contraindications
- •Evidence-Based Review
- •Endobronchial Valves
- •Airway Bypass Tracts
- •Coils
- •Other Methods of ELVR
- •Summary and Recommendations
- •References
- •36: Bronchial Thermoplasty
- •Introduction
- •Mechanism of Action
- •Trials
- •Long Term: Ten-Year Study
- •Patient Selection
- •Bronchial Thermoplasty Procedure
- •Equipment
- •Pre-procedure
- •Bronchoscopy
- •Post-procedure
- •Conclusion
- •References
- •Introduction
- •Bronchoalveolar Lavage (BAL)
- •Technical Aspects of BAL Procedure
- •ILD Cell Patterns and Diagnosis from BAL
- •Technical Advises for Conventional TLB and TLB-C in ILD
- •Future Directions
- •References
- •Introduction
- •The Pediatric Airway
- •Advanced Diagnostic Procedures
- •Endobronchial Ultrasound
- •Virtual Navigational Bronchoscopy
- •Cryobiopsy
- •Therapeutic Procedures
- •Dilation Procedures
- •Thermal Techniques
- •Mechanical Debridement
- •Endobronchial Airway Stents
- •Metallic Stents
- •Silastic Stents
- •Novel Stents
- •Endobronchial Valves
- •Bronchial Thermoplasty
- •Discussion
- •References
- •Introduction
- •Etiology
- •Congenital ADF
- •Malignant ADF
- •Cancer Treatment-Related ADF
- •Benign ADF
- •Iatrogenic ADF
- •Diagnosis
- •Treatment Options
- •Endoscopic Techniques
- •Stents
- •Clinical Results
- •Stent Complications
- •Other Available Stents
- •Other Endoscopic Methods
- •References
- •Introduction
- •Anatomy and Physiology of Swallowing
- •Functional Physiology of Swallowing
- •Epidemiology and Risk Factors
- •Types of Foreign Bodies
- •Organic
- •Inorganic
- •Mineral
- •Miscellaneous
- •Clinical Presentation
- •Acute FB
- •Retained FB
- •Radiologic Findings
- •Bronchoscopy
- •Airway Management
- •Rigid Vs. Flexible Bronchoscopy
- •Retrieval Procedure
- •Instruments
- •Grasping Forceps
- •Baskets
- •Balloons
- •Suction Instruments
- •Ablative Therapies
- •Cryotherapy
- •Laser Therapy
- •Electrocautery and APC
- •Surgical Management
- •Complications
- •Bleeding and Hemoptysis
- •Distal Airway Impaction
- •Iron Pill Aspiration
- •Follow-Up and Sequelae
- •Conclusion
- •References
- •Vascular Origin of Hemoptysis
- •History and Historical Perspective
- •Diagnostic Bronchoscopy
- •Therapeutic Bronchoscopy
- •General Measures
- •Therapeutic Bronchoscopy
- •Evidence-Based Review
- •Summary
- •Recommendations
- •References
- •History
- •“The Glottiscope” (1807)
- •“The Esophagoscope” (1895)
- •The Rigid Bronchoscope (1897–)
- •The Flexible Bronchoscope (1968–)
- •Transbronchial Lung Biopsy (1972) (Fig. 42.7)
- •Laser Therapy (1981–)
- •Endobronchial Stents (1990–)
- •Electromagnetic Navigation (2003–)
- •Bronchial Thermoplasty (2006–)
- •Endobronchial Microwave Therapy (2004–)
- •American Association for Bronchology and Interventional Pulmonology (AABIP) and Journal of Bronchology and Interventional Pulmonology (JOBIP) (1992–)
- •References
- •Index
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a |
b |
c
Fig. 41.4 (a) Vascular lesion in right upper lobe bronchus. (b) Tumoral in ltration at right B6. (c) Endobronchial mass in right upper lobe bronchus
Therapeutic Bronchoscopy
Therapeutic bronchoscopy is speci cally indicated to eliminate, at least transiently, a risk situation generally in the context of massive or threatening hemoptysis. Therefore, it is an urgent action applied in combination with other life support measures, which seek to recover and keep the patient clinically stable. Diagnosis can then be completed with imaging
techniques if the status of the patient allows, and de nitive treatment applied. Bronchial, systemic, and/or pulmonary embolization or surgical embolization can be used according to the situation.
Description oftheEquipment
See Table 41.2.
41 Hemoptysis, Endoscopic Management |
721 |
|
|
Table 41.2 Equipment: Material list frequently used in the management of hemoptysis
1. Bronchial block with fexible bronchoscope and sustained aspiration
2. Instillation of cold saline
3. Instillation of hemostatic drugs
• Vasoconstrictors |
• |
Adrenaline |
|
• |
Antidiuretic hormone |
|
|
derivatives |
•Tranexamic acid
•Fibrinogen-thrombin
•Biocompatible glue
4. Other bronchial blockade systems used in case series:
• |
Endobronchial stents |
• |
Ultrafex® (Boston |
|
|
|
Scienti c) |
• |
Silicone spigots |
• |
EWS® (Novatech) |
• Endobronchial valves |
• IBV® (Olympus) |
||
• |
Oxidized regenerated |
• |
Surgicel® (Ethicon) |
|
cellulose |
|
|
5. Coagulative therapies in endoscopically visible bleeding tumors
• Argon plasma |
• APC® (Erbe) |
coagulation |
|
•Photocoagulation
6.Orotracheal tube
7. Speci c orotracheal tubes
• |
Selective bronchial |
• TCB Univent® (Fuji) |
|
intubation |
|
|
|
|
8. Bronchial blockers |
|
|
|
|
|
• Embolectomy catheter |
• Edwards Fogarty® |
|
|
|
Catheter |
• |
Bronchial blockers |
• Arndt® (Cook) |
|
|
• Cohen® (Cook) |
|
|
• Uniblocker® (Fuji) |
|
|
• EZ-Blocker® (Rüsch) |
Adapted from Cordovilla et al. (2016) [7]. Copyright © 2016 SEPAR. Published by Elsevier España, S.L.U. All rights reserved
Application oftheTechnique
General Measures
First evaluation of the patient should be oriented to estimate the severity of the condition and decide which treatment is most convenient, and where will it take place.
Generally, hemoptoic sputum does not require hospitalization, but evident and life-threatening hemoptysis does. In the latter case, admission to the ICU is warranted.
Next, a quick and accurate diagnosis should be performed in order to locate the place of bleeding and determine its cause simultaneously.
The objectives of treatment are:
•\ To secure the airway
•\ To maintain adequate oxygenation •\ To achieve hemodynamic stability •\ To locate and stop bleeding
•\ To identify and treat the cause of hemoptysis
Management of the patient during hospital admission includes a series of general measures:
\1.\ Strict bed rest in lateral decubitus position, the affected side down, in order to protect the airway and prevent aspiration of blood into the unaffected lung.
\2.\ Monitoring of clinical parameters (blood pressure, heart and respiratory rate, oxygen saturation) and quanti cation of hemoptysis.
\3.\ Supplemental oxygen supply if necessary. \4.\ Suppression of cough by administering anti-
tussives, avoiding respiratory physiotherapy techniques.
\5.\ Empirical antibiotic treatment, useful in hemoptysis associated with respiratory infections and, in general, to prevent further complications.
\6.\ Nothing by mouth, to avoid aspiration to the airway, and to allow the performance of urgent tests such as bronchoscopy, CT, or arteriography.
\7.\ Establishment of large-bore venous access for fuid administration, availability of a blood reserve, and, if necessary, transfusion of packed red blood cells.
\8.\ Administration of anti brinolytic agents such as aminocaproic acid and tranexamic acid (TA); they act by inhibiting the clot dissolution process with the consequent reduction in bleeding. There are two clinical trials evaluating the use of TA (Amcha brin®), both inhaled and intravenously. Although patients with massive hemoptysis were not included, the results indicate that they may reduce the duration of bleeding and the need for interventional procedures [33, 34]. A review of
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published patient series concludes that the reduction in bleeding was associated to a low risk of short-term thromboembolic disease [35]. The recommended dose is 500 mg to 1 g intravenously two or three times per day.
Aminocaproic acid (Caproamin®) has been used in case series, as intracavitary instillation in aspergillomas [36, 37].
Protection oftheAirway
If there is severe respiratory failure or risk of suffocation (large and rapid bleeding), orotracheal intubation is required, preferably with a thick tube (8–9 mm) to facilitate diagnostic and interventional bronchoscopy [38].
In addition, bronchial blockade may be necessary to control bleeding in order to preserve ventilation of the healthy lung [18, 39]. There are several options to accomplish this:
\1.\ Perform the blockage with the orotracheal tube itself. This is possible in bleeding from the right bronchial tree, since the left main bronchus can be selectively intubated with the aid of the bronchoscope, so that the pneumatic balloon of the tube completely isolates the left lung. It should be taken into account that in tall patients the tube may not be long enough to adequately reach the main bronchus.
\2.\ Use independent bronchial blockers that are placed through a conventional tube:
\ (a)\ Edwards Fogarty® Catheter (n° 7 or higher). This infatable balloon is introduced parallel to the bronchoscope and it is placed at the selected location under direct vision. This maneuver can be facilitated by rotating the head to the opposite side, in a similar way as the left main bronchus intubation with the rigid bronchoscope, and bringing the end of the tube closer to the tracheal carina. This device cannot be securely anchored during long periods of time, but it may allow
blocking completely the bleeding site enough time for a clot to form and adhere. The introduction of the catheter independently of the bronchoscope instead of through its working channel allows continuous suctioning and improved vision.
\ (b)\ Arndt® Endobronchial Blocker (Fig. 41.5). It can be inserted transiently attached to the end of the bronchoscope to be transported to its location [11–13]. It has a transparent head with three ports: one to x the catheter of the blocking balloon, another for the introduction of the bronchoscope, and the third one for the connection to the ventilator.
\(c)\ Cohen® Endobronchial Blocker. It is a balloon catheter curved at its distal end to facilitate placement.
\(d)\ EZ-Blocker®. This catheter has aY-shaped distal end, to facilitate anchoring in the tracheal carina, and two balloons that can be infated separately.
\3.\ Perform intubation and blockage with a special orotracheal tube:
\(a)\ Torque Control Blocker Univent Tube®: This has a bronchial blocker that prolongs the tube itself, designed to occlude any major bronchi with the tube located inside the trachea (Fig. 41.6).
\(b)\ Bronchofex ®: This particular tube has a catheter on the outside, through which a Fogarty or similar tool can be inserted, and also provides an external xation system. Its advantage is that it fully preserves the internal gauge of the tube and facilitates the location of the balloon in any of the main bronchi by rotating the orotracheal tube on its major axis.
\(c)\ Double-lumen tube: This particular tube allows the blockade of the bleeding site performing selective intubation. Given its reduced caliber, it is not possible to introduce the standard bronchoscope through it, and it is also dif cult to anchor since the bleeding site is not directly visible.
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Fig. 41.5 Arndt catheter. (a) Catheter xed at the distal end of the fexible bronchoscope. (b) Flexible bronchoscope introduced through the three-headed piece. (c) Catheter placed at the selected site
Therapeutic Bronchoscopy
In our experience, fexible bronchoscopy is therst procedure indicated when a patient presents with life-threatening hemoptysis, and hemodynamic instability. It can be performed in the intensive care setting or any other critical area. When a rigid bronchoscope is available, it is advisable to intubate with the rigid tube and through it introduce the fexible endoscope. They can complement each other taking advantage of both instruments:
•\ Ventilate the patient properly.
•\ Ensure airway permeability by aspiration of blood and clots with large-caliber probes.
•\ Perform direct hemostasis on bleeding areas, pressing with the external wall of the distal end of the rigid bronchoscope or by the application of vasoconstrictors or endobronchial coagulant therapies.
•\ Access the distal bronchial tree.
Therefore, the rigid bronchoscope supplemented with the fexible bronchoscope is the
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Fig. 41.6 (a) Univent tube. (b) Univent tube at the trachea, after hemoptysis. (c) Infated balloon at the level of the bleeding bronchus
most complete and safe procedure in life- threatening hemoptysis [39, 40]. However, fexible bronchoscopy remains the most used procedure in these cases, given its broad availability. Rigid bronchoscopy is less available, it requires a special training that not many pulmonary physicians have, and it has to be used in the operating room under general anesthesia or conscious sedation. That implies moving an unstable patient, a risk that may not be affordable in a life- threatening situation.
Once the origin of the bleeding has been identi ed, if a lung blockade is not necessary, local measures can be applied. Their clinical ef cacy is limited, as well as the published evidence.
In addition to the methods described above, other interventional procedures can be performed:
\1.\ Bronchial blockade with the fexible bronchoscope and sustained aspiration in order to cause segmental collapse and stop the bleeding.
\2.\ Selective bronchial blockage through the working channel of the bronchoscope:
\(a)\ Fogarty n° 5 (5 Fr.) or a similar type of balloon catheter (Olympus B5-2C® and B7-2C® balloon).
\(b)\ Longer catheters such as the Olympus Multi-3 V Plus B-V232P-A® balloon catheter. This one is a 190-cm catheter that can be inserted through a working channel of 2.8 mm, and insuffated up to 15 mm in diameter. Without defating the balloon, it can be clamped and cut to stay in place andnally remove the bronchoscope.
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\3.\ Selective bronchial blockade using a guide wire: A guide is inserted through the working channel to the chosen bronchus and after removal of the bronchoscope a balloon catheter is placed through the guide. Although this procedure is technically more complicated, it allows the balloon catheter to be located and the bronchoscope removed [41].
The balloon can be infated for up to 24–48 h to allow clot formation, although it can be maintained in the airway for up to several days. To prevent mucosal ischemia, it is necessary to defate it periodically, at least three times a day [42], always under endoscopic vision in order to re-infate immediately if bleeding persists. If the patient does not bleed again after several hours, the cathe- ter-balloon is withdrawn.
\4.\ Washing of the bronchus with cold saline serum (4°C) using aliquots of 50 mL until bleeding is suppressed, without exceeding 500 mL total volume [43]. The mechanism of action is local vasoconstriction although there are no controlled studies that demonstrate its effectiveness [44].
\5.\ Instillation of hemostatic drugs:
\(a)\ Vasoconstrictors: Adrenaline diluted to 1:20,000 and applied through the working channel in 1 mL aliquots. Its effect has not been compared in controlled trials and only clinical experience supports its use. In order to minimize its cardiovascular effects in patients at risk, it has been suggested to substitute it for some antidiuretic hormone derivatives such as terlipressin or ornipressin, although reports are anecdotic [45, 46].
\(b)\ Tranexamic acid can be instilled undiluted on the bleeding site, with an initial dose of 500 mg [47, 48].
\(c)\ Fibrinogen-thrombin (Tissucol®): It has been used in two case series in hemoptysis cases that could not be controlled with other endoscopic procedures. [49]
\(d)\ Thrombin slurry: A series of 13 patients showed that hemostasis was achieved in 77% of patients [50].
\ (e)\ Recombinant activated factor VII: Topical hemostatics are not useful in fast and severe hemoptysis, since the blood washes out the hemostatic agent diminishing or abolishing its ef cacy. Described in a small series of cases.
\6.\ Other bronchial blockade systems that have been used successfully in series of cases:
\ (a)\ Oxidized regenerated cellulose (Surgicel®): A report by Valipour et al. [49] describes how fragments of this hemostatic and resorbable mesh were introduced into the segmental or subsegmental bronchi causing the hemorrhage to stop. They were previously introduced through the working channel of a standard bronchoscope by pulling them with a fat blade forceps. Once the bleeding site was located, they were pushed into the segmental bronchus with the same forceps. In total, four to ten fragments of 3 × 4 cm were introduced, until hemostasis was achieved. As it was a resorbable material, it was not necessary to extract it later, and the absence of bronchial sequelae was later veri ed.
\(b)\ Endobronchial valves: Designed for endoscopic volume reduction, these are used for other purposes such as persistent air leakage or bronchopleural stula. Isolated cases of their application in the treatment of hemoptysis have also been described [51].
\(c)\ Silicone plugs (Watanabe spigots) [52, 53]: Initially introduced by Watanabe for endoscopic treatment of bronchopleural stulas, they have demonstrated their ef cacy in the transient tamponade of hemorrhagic segmental bronchi. The insertion and removal are performed by apprehending them with a biopsy forceps, and transporting them at the end of the broncho berscope. A series of cases reported by Bylicki accounted for a success rate of 78% [9].
\(d)\ Stents: In a series of eight patients with cancer-related hemoptysis, bleeding ceased in 75% after stent placement [54].
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