- •Foreword
- •Preface
- •Contents
- •About the Editors
- •Contributors
- •1: Tracheobronchial Anatomy
- •Trachea
- •Introduction
- •External Morphology
- •Internal Morphology
- •Mucous Layer
- •Blood Supply
- •Anatomo-Clinical Relationships
- •Bronchi
- •Main Bronchi
- •Bronchial Division
- •Left Main Bronchus (LMB)
- •Right Main Bronchus (RMB)
- •Blood Supply
- •References
- •2: Flexible Bronchoscopy
- •Introduction
- •History
- •Description
- •Indications and Contraindications
- •Absolute Contraindications
- •Procedure Preparation
- •Technique of FB Procedure
- •Complications of FB Procedure
- •Basic Diagnostic Procedures
- •Bronchoalveolar Lavage (BAL)
- •Transbronchial Lung Biopsy (TBLB)
- •Transbronchial Needle Aspiration (TBNA)
- •Bronchial Brushings
- •Advanced Diagnostic Bronchoscopy
- •EBUS-TBNA
- •Ultrathin Bronchoscopy
- •Transbronchial Lung Cryobiobsy (TBLC)
- •Therapeutic Procedures Via FB
- •LASER Bronchoscopy
- •Electrocautery
- •Argon Plasma Coagulation (APC)
- •Cryotherapy
- •Photodynamic Therapy
- •Airway Stent Placement
- •Endobronchial Valve Placement
- •Conclusion
- •References
- •History and Historical Perspective
- •Indications and Contraindications
- •Procedure Description
- •Procedure Planning
- •Target Approximation
- •Sampling
- •Complications
- •Future Directions
- •Summary and Recommendations
- •References
- •4: Rigid Broncoscopy
- •Innovations
- •Ancillary Equipment
- •Rigid Bronchoscopy Applications
- •Laser Bronchoscopy
- •Tracheobronchial Prosthesis
- •Transbronchial Needle Aspiration (TBNA)
- •Rigid Bronchoscope in Other Treatments for Bronchial Obstruction
- •Mechanical Debridement
- •Pediatric Rigid Bronchoscopy
- •Tracheobronchial Dilatation
- •Foreign Bodies Removal
- •Other Indications
- •Complications
- •The Procedure
- •Some Conclusions
- •References
- •History and Historical Perspective
- •Indications and Contraindications
- •Preprocedural Evaluation and Preparation
- •Physical Examination
- •Procedure-Related Indications
- •Application of the Technique
- •Topical Anesthesia
- •Anesthesia of the Nasal Mucosa and Nasopharynx
- •Anesthesia of the Mouth and Oropharynx
- •Superior Laryngeal Nerve Block
- •Recurrent Laryngeal Nerve Block (RLN)
- •Conscious Sedation
- •Monitored Anesthesia Care (MAC)
- •General Anesthesia
- •Monitoring the Depth of Anesthesia
- •Interventional Bronchoscopy Suites
- •Airway Devices
- •Laryngeal Mask Airway (LMA)
- •Endotracheal Tube (ETT)
- •Rigid Bronchoscope
- •Modes of Ventilation
- •Spontaneous Ventilation
- •Assisted Ventilation
- •Noninvasive Positive Pressure Ventilation (NIV)
- •Positive Pressure Controlled Mechanical Ventilation
- •Jet Ventilation
- •Electronic Mechanical Jet Ventilation
- •Postprocedure Care
- •Special Consideration
- •Anesthesia for Peripheral Diagnostic and Therapeutic Bronchoscopy
- •Anesthesia for Interventional Bronchoscopic Procedures During the COVID-19 Pandemic
- •Summary and Recommendations
- •Conclusion
- •References
- •Background
- •Curricular Structure and Delivery
- •What Is a Bronchoscopy Curriculum?
- •Tradition, Teaching Styles, and Beliefs
- •Using Assessment Tools to Guide the Educational Process
- •The Ethics of Teaching
- •When Learners Teach: The Journey from Novice to Mastery and Back Again
- •The Future Is Now
- •References
- •Interventional Procedure
- •Assessment of Flow–Volume Curve
- •Dyspnea
- •Analysis of Pressure–Pressure Curve
- •Conclusions
- •References
- •Introduction
- •Adaptations of the IP Department
- •Environmental Control
- •Personal Protective Equipment
- •Procedure Performance
- •Bronchoscopy in Intubated Patients
- •Other Procedures in IP Unit
- •References
- •Introduction
- •Safety
- •Patient Safety
- •Provider Safety
- •Patient Selection and Screening
- •Lung Cancer Diagnosis and Staging
- •Inpatients
- •COVID-19 Clearance
- •COVID Clearance: A Role for Bronchoscopy
- •Long COVID: A Role for Bronchoscopy
- •Preparing for the Next Pandemic
- •References
- •Historical Perspective
- •Indications and Contraindications
- •Evidence-Based Review
- •Summary and Recommendations
- •References
- •Introduction
- •Clinical Presentation
- •Diagnosis
- •Treatment
- •History and Historical Perspectives
- •Indications and Contraindications
- •Benign and Malignant Tumors
- •Tumors with Uncertain Prognosis
- •Application of the Technique
- •Evidence Based Review
- •Summary and Recommendations
- •References
- •12: Cryotherapy and Cryospray
- •Introduction
- •Historical Perspective
- •Equipment
- •Cryoadhesion
- •Indications
- •Cryorecanalization
- •Cryoadhesion and Foreign Body Removal
- •Cryoadhesion and Mucus Plugs/Blood Clot Retrieval
- •Endobronchial Cryobiopsy
- •Transbronchial Cryobiopsy for Lung Cancer
- •Safety Concerns and Contraindications
- •Cryoablation
- •Indications
- •Evidence
- •Safety Concerns and Contraindications
- •Cryospray
- •Indications
- •Evidence
- •Safety Concerns and Contraindications
- •Advantages of Cryotherapy
- •Limitations
- •Future Research Directions
- •References
- •13: Brachytherapy
- •History and Historical Perspective
- •Indications and Contraindications
- •Application of the Technique
- •Evidence-Based Review
- •Adjuvant Treatment
- •Palliative Treatment
- •Complications
- •Summary and Recommendations
- •References
- •14: Photodynamic Therapy
- •Introduction
- •Photosensitizers
- •First-Generation Photosensitizers
- •M-Tetrahidroxofenil Cloro (mTHPC) (Foscan®)
- •PDT Reaction
- •Tumor Damage Process
- •Procedure
- •Indications
- •Curative PDT Indications
- •Palliative PDT Indications
- •Contraindications
- •Rationale for Use in Early-Stage Lung Cancer
- •Rationale
- •PDT in Combination with Other Techniques for Advanced-Stage Non-small Cell Lung Cancer
- •Commentary
- •Complementary Endoscopic Methods for PDT Applications
- •New Perspectives
- •Other PDT Applications
- •Conclusions
- •References
- •15: Benign Airways Stenosis
- •Etiology
- •Congenital Tracheal Stenosis
- •Iatrogenic
- •Infectious
- •Idiopathic Tracheal Stenosis
- •Distal Bronchial Stenosis
- •Diagnosis Methods
- •Patient History
- •Imaging Techniques
- •Bronchoscopy
- •Pulmonary Function Test
- •Treatment
- •Endoscopic Treatment
- •Dilatation
- •Laser Therapy
- •Stents
- •How to Proceed
- •Stent Placement
- •Placing a Montgomery T Tube
- •The Rule of Twos for Benign Tracheal Stenosis (Fig. 15.23)
- •Surgery
- •Summary and Recommendations
- •References
- •16: Endobronchial Prostheses
- •Introduction
- •Indications
- •Extrinsic Compression
- •Intraluminal Obstruction
- •Stump Fistulas
- •Esophago-respiratory Fistulas (ERF)
- •Expiratory Central Airway Collapse
- •Physiologic Rationale for Airway Stent Insertion
- •Stent Selection Criteria
- •Stent-Related Complications
- •Granulation Tissue
- •Stent Fracture
- •Migration
- •Contraindications
- •Follow-Up and Patient Education
- •References
- •Introduction
- •Overdiagnosis
- •False Positives
- •Radiation
- •Risk of Complications
- •Lung Cancer Screening Around the World
- •Incidental Lung Nodules
- •Management of Lung Nodules
- •References
- •Introduction
- •Minimally Invasive Procedures
- •Mediastinoscopy
- •CT-Guided Transthoracic Biopsy
- •Fluoroscopy-Guided Transthoracic Biopsies
- •US-Guided Transthoracic Biopsy
- •Thoracentesis and Pleural Biopsy
- •Thoracentesis
- •Pleural Biopsy
- •Surgical or Medical Thoracoscopy
- •Image-Guided Pleural Biopsy
- •Closed Pleural Biopsy
- •Image-Guided Biopsies for Extrathoracic Metastases
- •Tissue Acquisition, Handling and Processing
- •Implications of Tissue Acquisition
- •Guideline Recommendations for Tissue Acquisition in Mediastinal Staging
- •Methods to Overcome Challenges in Tissue Acquisition and Genotyping
- •Rapid on-Site Evaluation (ROSE)
- •Sensitive Genotyping Assays
- •Liquid Biopsy
- •Summary, Recommendations and Highlights
- •References
- •History
- •Data Source and Methodology
- •Tumor Size
- •Involvement of the Main Bronchus
- •Atelectasis/Pneumonitis
- •Nodal Staging
- •Proposal for the Revision of Stage Groupings
- •Small Cell Lung Cancer (SCLC)
- •Discussion
- •Methodology
- •T Descriptors
- •N Descriptors
- •M Descriptors
- •Summary
- •References
- •Introduction
- •Historical Perspective
- •Fluoroscopy
- •Radial EBUS Mini Probe (rEBUS)
- •Ultrasound Bronchoscope (EBUS)
- •Virtual Bronchoscopy
- •Trans-Parenchymal Access
- •Cone Beam CT (CBCT)
- •Lung Vision
- •Sampling Instruments
- •Conclusions
- •References
- •History and Historical Perspective
- •Narrow Band Imaging (NBI)
- •Dual Red Imaging (DRI)
- •Endobronchial Ultrasound (EBUS)
- •Optical Coherence Tomography (OCT)
- •Indications and Contraindications
- •Confocal Laser Endomicroscopy and Endocytoscopy
- •Raman Spectrophotometry
- •Application of the Technique
- •Supplemental Technology for Diagnostic Bronchoscopy
- •Evidence-Based Review
- •Summary and Recommendations, Highlight of the Developments During the Last Three Years (2013 on)
- •References
- •Introduction
- •History and Historical Perspective
- •Endoscopic AF-OCT System
- •Preclinical Studies
- •Clinical Studies
- •Lung Cancer
- •Asthma
- •Airway and Lumen Calibration
- •Obstructive Sleep Apnea
- •Future Applications
- •Summary
- •References
- •23: Endobronchial Ultrasound
- •History and Historical Perspective
- •Equipment
- •Technique
- •Indication, Application, and Evidence
- •Convex Probe Ultrasound
- •Equipment
- •Technique
- •Indication, Application, and Evidence
- •CP-EBUS for Malignant Mediastinal or Hilar Adenopathy
- •CP-EBUS for the Staging of Non-small Cell Lung Cancer
- •CP-EBUS for Restaging NSCLC After Neoadjuvant Chemotherapy
- •Complications
- •Summary
- •References
- •Introduction
- •What Is Electromagnetic Navigation?
- •SuperDimension Navigation System (EMN-SD)
- •Computerized Tomography
- •Computer Interphase
- •The Edge Catheter: Extended Working Channel (EWC)
- •Procedural Steps
- •Planning
- •Detecting Anatomical Landmarks
- •Pathway Planning
- •Saving the Plan and Exiting
- •Registration
- •Real-Time Navigation
- •SPiN System Veran Medical Technologies (EMN-VM)
- •Procedure
- •Planning
- •Navigation
- •Biopsy
- •Complications
- •Limitations
- •Summary
- •References
- •Introduction
- •Image Acquisition
- •Hardware
- •Practical Considerations
- •Radiation Dose
- •Mobile CT Studies
- •Future Directions
- •Conclusion
- •References
- •26: Robotic Assisted Bronchoscopy
- •Historical Perspective
- •Evidence-Based Review
- •Diagnostic Yield
- •Monarch RAB
- •Ion Endoluminal Robotic System
- •Summary
- •References
- •History and Historical Perspective
- •Indications and Contraindications
- •General
- •Application of the Technique
- •Preoperative Care
- •Patient’s Position and Operative Field
- •Incision and Initial Dissection
- •Palpation
- •Biopsy
- •Control of Haemostasis and Closure
- •Postoperative Care
- •Complications
- •Technical Variants
- •Extended Cervical Mediastinoscopy
- •Mediastinoscopic Biopsy of Scalene Lymph Nodes
- •Inferior Mediastinoscopy
- •Mediastino-Thoracoscopy
- •Video-Assisted Mediastinoscopic Lymphadenectomy
- •Transcervical Extended Mediastinal Lymphadenectomy
- •Evidence-Based Review
- •Summary and Recommendations
- •References
- •Introduction
- •Case 1
- •Adrenal and Hepatic Metastases
- •Brain
- •Bone
- •Case 1 Continued
- •Biomarkers
- •Case 1 Concluded
- •Case 2
- •Chest X-Ray
- •Computerized Tomography
- •Positive Emission Tomography
- •Magnetic Resonance Imaging
- •Endobronchial Ultrasound with Transbronchial Needle Aspiration
- •Transthoracic Needle Aspiration
- •Transbronchial Needle Aspiration
- •Endoscopic Ultrasound with Needle Aspiration
- •Combined EUS-FNA and EBUS-TBNA
- •Case 2 Concluded
- •Case 3
- •Standard Cervical Mediastinoscopy
- •Extended Cervical Mediastinoscopy
- •Anterior Mediastinoscopy
- •Video-Assisted Thoracic Surgery
- •Case 3 Concluded
- •Case 4
- •Summary
- •References
- •29: Pleural Anatomy
- •Pleural Embryonic Development
- •Pleural Histology
- •Cytological Characteristics
- •Mesothelial Cells Functions
- •Pleural Space Defense Mechanism
- •Pleura Macroscopic Anatomy
- •Visceral Pleura (Pleura Visceralis or Pulmonalis)
- •Parietal Pleura (Pleura Parietalis)
- •Costal Parietal Pleura (Costalis)
- •Pleural Cavity (Cavitas Thoracis)
- •Pleural Apex or Superior Pleural Sinus [12–15]
- •Anterior Costal-Phrenic Sinus or Cardio-Phrenic Sinus
- •Posterior Costal-Phrenic Sinus
- •Cost-Diaphragmatic Sinus or Lateral Cost-Phrenic Sinus
- •Fissures18
- •Pleural Vascularization
- •Parietal Pleura Lymphatic Drainage
- •Visceral Pleura Lymphatic Drainage
- •Pleural Innervation
- •References
- •30: Chest Ultrasound
- •Introduction
- •The Technique
- •The Normal Thorax
- •Chest Wall Pathology
- •Pleural Pathology
- •Pleural Thickening
- •Pneumothorax
- •Pulmonary Pathology
- •Extrathoracic Lymph Nodes
- •COVID and Chest Ultrasound
- •Conclusions
- •References
- •Introduction
- •History of Chest Tubes
- •Overview of Chest Tubes
- •Contraindications for Chest Tube Placement
- •Chest Tube Procedural Technique
- •Special Considerations
- •Pneumothorax
- •Empyema
- •Hemothorax
- •Chest Tube Size Considerations
- •Pleural Drainage Systems
- •History of and Introduction to Indwelling Pleural Catheters
- •Indications and Contraindications for IPC Placement
- •Special Considerations
- •Non-expandable Lung
- •Chylothorax
- •Pleurodesis
- •Follow-Up and IPC Removal
- •IPC-Related Complications and Management
- •Competency and Training
- •Summary
- •References
- •32: Empyema Thoracis
- •Historical Perspectives
- •Incidence
- •Epidemiology
- •Pathogenesis
- •Clinical Presentation
- •Radiologic Evaluation
- •Biochemical Analysis
- •Microbiology
- •Non-operative Management
- •Prognostication
- •Surgical Management
- •Survivorship
- •Summary and Recommendations
- •References
- •Evaluation
- •Initial Intervention
- •Pleural Interventions for Recurrent Symptomatic MPE
- •Especial Circumstances
- •References
- •34: Medical Thoracoscopy
- •Introduction
- •Diagnostic Indications for Medical Thoracoscopy
- •Lung Cancer
- •Mesothelioma
- •Other Tumors
- •Tuberculosis
- •Therapeutic Indications
- •Pleurodesis of Pneumothorax
- •Thoracoscopic Drainage
- •Drug Delivery
- •Procedural Safety and Contraindications
- •Equipment
- •Procedure
- •Pre-procedural Preparations and Considerations
- •Procedural Technique [32]
- •Medical Thoracoscopy Versus VATS
- •Conclusion
- •References
- •Historical Perspective
- •Indications and Contraindications
- •Evidence-Based Review
- •Endobronchial Valves
- •Airway Bypass Tracts
- •Coils
- •Other Methods of ELVR
- •Summary and Recommendations
- •References
- •36: Bronchial Thermoplasty
- •Introduction
- •Mechanism of Action
- •Trials
- •Long Term: Ten-Year Study
- •Patient Selection
- •Bronchial Thermoplasty Procedure
- •Equipment
- •Pre-procedure
- •Bronchoscopy
- •Post-procedure
- •Conclusion
- •References
- •Introduction
- •Bronchoalveolar Lavage (BAL)
- •Technical Aspects of BAL Procedure
- •ILD Cell Patterns and Diagnosis from BAL
- •Technical Advises for Conventional TLB and TLB-C in ILD
- •Future Directions
- •References
- •Introduction
- •The Pediatric Airway
- •Advanced Diagnostic Procedures
- •Endobronchial Ultrasound
- •Virtual Navigational Bronchoscopy
- •Cryobiopsy
- •Therapeutic Procedures
- •Dilation Procedures
- •Thermal Techniques
- •Mechanical Debridement
- •Endobronchial Airway Stents
- •Metallic Stents
- •Silastic Stents
- •Novel Stents
- •Endobronchial Valves
- •Bronchial Thermoplasty
- •Discussion
- •References
- •Introduction
- •Etiology
- •Congenital ADF
- •Malignant ADF
- •Cancer Treatment-Related ADF
- •Benign ADF
- •Iatrogenic ADF
- •Diagnosis
- •Treatment Options
- •Endoscopic Techniques
- •Stents
- •Clinical Results
- •Stent Complications
- •Other Available Stents
- •Other Endoscopic Methods
- •References
- •Introduction
- •Anatomy and Physiology of Swallowing
- •Functional Physiology of Swallowing
- •Epidemiology and Risk Factors
- •Types of Foreign Bodies
- •Organic
- •Inorganic
- •Mineral
- •Miscellaneous
- •Clinical Presentation
- •Acute FB
- •Retained FB
- •Radiologic Findings
- •Bronchoscopy
- •Airway Management
- •Rigid Vs. Flexible Bronchoscopy
- •Retrieval Procedure
- •Instruments
- •Grasping Forceps
- •Baskets
- •Balloons
- •Suction Instruments
- •Ablative Therapies
- •Cryotherapy
- •Laser Therapy
- •Electrocautery and APC
- •Surgical Management
- •Complications
- •Bleeding and Hemoptysis
- •Distal Airway Impaction
- •Iron Pill Aspiration
- •Follow-Up and Sequelae
- •Conclusion
- •References
- •Vascular Origin of Hemoptysis
- •History and Historical Perspective
- •Diagnostic Bronchoscopy
- •Therapeutic Bronchoscopy
- •General Measures
- •Therapeutic Bronchoscopy
- •Evidence-Based Review
- •Summary
- •Recommendations
- •References
- •History
- •“The Glottiscope” (1807)
- •“The Esophagoscope” (1895)
- •The Rigid Bronchoscope (1897–)
- •The Flexible Bronchoscope (1968–)
- •Transbronchial Lung Biopsy (1972) (Fig. 42.7)
- •Laser Therapy (1981–)
- •Endobronchial Stents (1990–)
- •Electromagnetic Navigation (2003–)
- •Bronchial Thermoplasty (2006–)
- •Endobronchial Microwave Therapy (2004–)
- •American Association for Bronchology and Interventional Pulmonology (AABIP) and Journal of Bronchology and Interventional Pulmonology (JOBIP) (1992–)
- •References
- •Index
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Pulmonary function tests and assessment of arterial blood gases may be required depending on the nature of the procedure and/or the severity of the pulmonary compromise [5].
Informed consent should be obtained from the patient after detailed explanation of the risks, bene ts, and possible alternatives of the procedure and sedation or anesthesia.
Nothing per os (NPO) is indicated for 2 h for clear liquids and 6–8 h for solids before the procedure according to the current ASA guidelines. Patients with history of uncontrolled or untreated acid refux, postesophagectomy, or gastroparesis should be instructed to take their antirefux medication on the day of the procedure and can bene t from airway protection by endotracheal intubation.
Procedure-Related Indications
Despite few reports of rigid bronchoscopy performed under local anesthesia [7] or general anesthesia with spontaneous ventilation, the most common practice is to perform rigid bronchoscopy under general anesthesia with muscle relaxation [4]. The rationale for utilizing general anesthesia for rigid bronchoscopy is the lengthy nature of the procedures and the concurrence of hypoxemia and hypercapnia [8]. Spontaneous, assisted, mechanical, or jet ventilation can be used during rigid bronchoscopy to maintain adequate oxygenation and carbon dioxide elimination [9].
Controversy exists over performing EBUS under moderate sedation or general anesthesia. The EBUS bronchoscope has a larger external diameter of 6.9 mm and is more tolerated when inserted through the mouth compared to the nose. Therefore, some practitioners prefer to perform all EBUS procedures or only the lengthy staging EBUS procedures under general anesthesia. Recent study showed that more lymph nodes per patient and smaller lymph nodes were sampled more often when EBUS was performed under deep sedation or general anesthesia. In addition, onsite cytology evaluation was used more frequently when general anesthesia was used [10]. However, several reports indicated no difference
in patient satisfaction, yield, sensitivity, or speci-city of the EBUS procedure when performed under moderate sedation versus general anesthesia [11, 12].
Application of the Technique
Topical Anesthesia
Local anesthetics cause reversible block of the conduction of nerve impulses with subsequent sensory, motor, and autonomic blockade. Cocaine was the rst topical anesthetic discovered, but it was soon found to cause topical irritation and psychological dependence. Subsequently, synthetic local anesthetics lacking such side effects were discovered. Procaine, the rst synthetic local anesthetic, was introduced by Einhorn in 1905 and was followed by lidocaine, which was synthesized in 1943 by Löfgren. Synthetic local anesthetics have a lipophilic benzene ring linked via an amide or an ester bond to a hydrocarbon chain that is attached to a hydrophilic tertiary amine structure. Local anesthetics are classi ed according to the type of their linking bond to ester or amide local anesthetics. The nature of the linking bond affects the metabolism of the local anesthetic as well as its potential to produce an allergic reaction. Amide local anesthetics, which are commonly used in bronchoscopy, are metabolized by the liver microsomal enzymes and are also extracted through the lungs. The addition of epinephrine at 1:200,0000 (5 μg/mL) concentration or 0.25% phenylephrine causes local vasoconstriction, which slows down the absorption of the local anesthetic, prolongs its duration of action, and decreases its systemic toxicity.
Side Efects of Local Anesthetics
Absorption of large amounts of local anesthetics from the application site or direct accidental intravascular injection of large dose can result in systemic toxicity, e.g., lidocaine plasma level of (5 μg/mL) or greater than 8.2 mg/kg of lidocaine instilled in the airway can result in systemic toxicity [13].
Central nervous system (CNS) toxicity initially presents with symptoms of CNS excita-
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tion such as restlessness, vertigo, tinnitus, and slurred speech. The symptoms may progress to tonic–clonic seizure followed by CNS depression in the form of coma and possibly death. Seizures should be immediately treated with small doses of intravenous benzodiazepine (diazepam or midazolam), intravenous thiopental, or propofol. Hypoxemia should be treated with supplemental oxygen. Additionally, hyperventilation with subsequent respiratory alkalosis causes hyperpolarization of the nerve membrane thus increasing the threshold for seizure and the amount of local anesthetic bound to protein causing a decrease in the delivery of free drug to the brain. If seizures continue despite treatment, intubation is warranted to protect the airway.
Cardiovascular toxicity due to blockade of the cardiac sodium channels can result in hypotension, long PR interval, and widening of the QRS complex. More severe cardiotoxicity can present with severe hypotension, cardiac arrhythmias, and atrioventricular heart block.
Methemoglobinemia occurs when local anesthetic oxidizes the iron molecule in the hemoglobin from the ferrous to ferric state. Hemoglobin with iron molecules in the ferric state is called methemoglobin and is characterized by its inability to release bound oxygen to tissue. Patients with methemoglobinemia present with cyanosis, chocolate-colored blood, stupor, coma, and death. Methemoglobinemia is easily treated by the administration of 1–2 mg/kg of methylene blue intravenously.
Allergic reactions to local anesthetics are rare but are more common with ester local anesthetic metabolite para-aminobenzoic acid (PABA). In addition, the preservatives used with either ester or amide local anesthetics (e.g., methylparaben) can be a source of allergic reaction. It is noteworthy that cross-sensitivity does not exist between ester and amide local anesthetics.
Anesthesia of the Nasal Mucosa and Nasopharynx
Sensation to the nasal mucosa is provided by the middle division (V2) of the trigeminal nerve (CN V), the sphenopalatine ganglion, and the ethmoid
nerve. The nasal mucosa and the nasopharynx can be topicalized using a cotton-tipped applicator or pledgets soaked in a 1%, 2%, or 4% lidocaine solution with or without a vasoconstricting agent. The applicators are placed sequentially along the inferior turbinate, the middle turbinate, and the superior turbinate. Each applicator should be left in place for 5 min.
Anesthesia of the Mouth and Oropharynx
Sensation of the mouth and oropharynx is supplied by branches of the glossopharyngeal, vagus, and facial nerves. The lingual branch of the glossopharyngeal nerve provides sensation to the posterior third of the tongue, the vallecula, and the anterior surface of the epiglottis. The pharyngeal branch provides sensation to the posterior and lateral walls of the pharynx, and the tonsillar branch supplies the tonsillar pillars. The tongue can be anesthetized by placing a tongue blade coated with lidocaine gel on the tongue for several minutes. Oral and pharyngeal mucosa are anesthetized by inhalation of nebulized 4% lidocaine or 0.5% tetracaine or by using a cetacaine atomizer spray (tetracaine and benzocaine combination). Gargle with 2–4 mL of viscous lidocaine for 30 s can provide additional anesthesia to the posterior pharyngeal wall.
Superior Laryngeal Nerve Block
The superior laryngeal nerve (SLN) is a branch of the vagus nerve that divides lateral to the cornu of the hyoid bone into internal and external branches. The internal branch passes under the greater cornu of the hyoid bone before piercing the thyrohyoid membrane and entering the pyriform recess where it provides sensory innervation to the base of the tongue, the superior epiglottis, the aryepiglottic folds, the arytenoids, and the laryngeal mucosa above the vocal cords. The external branch supplies motor innervation to the cricothyroid muscle.
To perform SLN block, the patient should be placed in a supine position with the head slightly extended; the greater horn of the hyoid bone is palpated above the thyroid cartilage. The nee-
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Fig. 5.2 Superior laryngeal nerve block
dle (size 22 or 23 gauge) is inserted toward the greater horn of the hyoid bone and then moved caudally until a pop is felt when the thyroid ligament is pierced at a depth of about 1–2 cm. Negative aspiration is then followed by injecting 2–3 mL of 2% lidocaine with epinephrine. Bilateral blocks should be performed (Fig. 5.2).
Recurrent Laryngeal Nerve Block (RLN)
The recurrent laryngeal provides motor innervation to the vocal cords and sensory innervation to both the trachea and vocal cords. In a supine patient with hyperextended neck, the skin over the cricothyroid membrane is anesthetized with lidocaine 1–2% with a 22-gauge needle. A 22-gauge IV catheter is then inserted through the cricothyroid membrane into the tracheal lumen at an angle of 45° caudally. Air should be aspirated to con rm intratracheal position. The needle should then be removed leaving the plastic catheter in the tracheal lumen. The patient is asked to take a deep breath followed by forced exhalation, while 3–4 cc of 1–2% or 4% lidocaine is injected through the catheter. This maneuver commonly results in coughing that aids in the spread of the local anesthetic over the vocal cords and the trachea.
Conscious Sedation
The American College of Chest Physicians has suggested in its consensus statement in 2011 that all physicians performing bronchoscopy should consider using topical anesthesia, analgesic, and sedative agents, when feasible [14]. The advantages of conscious sedation are the reduction of patient anxiety, pain, airway refexes such as cough and gag, and the dyspnea associated with the insertion of the bronchoscope. Amnesia from the procedure also increases patient satisfaction and willingness to undergo another bronchoscopic procedure. In addition, the ability of the bronchoscopist to adequately perform advanced diagnostic and therapeutic procedures in shorter duration improves with sedation.
Different drug regimens have been used, and they vary depending on the bronchoscopist’s preference and experience. The most commonly used classes of drugs are benzodiazepines for anxiolysis and amnesia in combination with opioids for suppression of cough and pain. The combination of narcotics and benzodiazepines has an additive effect on the suppression of the respiratory drive and cardiovascular hemodynamics thus increasing the likelihood of apnea, desaturation, and hypotension. Therefore, these drugs should be titrated gradually to achieve the desired effect and avoid undesired side effects.
Benzodiazepines act primarily by enhancing the action of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), causing increased resistance of neuronal excitation. This translates clinically to anxiolysis, sedation, anterograde amnesia, centrally mediated muscle relaxation, and minimal depression of the ventilation and the cardiovascular system. When compared with no sedation for bronchoscopy, benzodiazepine, as a single sedating agent, was associated with increased patient satisfaction and willingness to undergo another bronchoscopy. However, the postprocedure recovery time was longer in the benzodiazepine-treated patients without an increase in complication rates [15].
The three commonly used benzodiazepines for procedural sedation are midazolam, diazepam, and lorazepam. Midazolam is the most preferred
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M. Sarkiss |
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benzodiazepine because of its water solubility, absence of pain with injection, rapid onset, short duration of action, and rapid clearance. The average dose of midazolam is 0.06–0.07 mg/kg with special consideration to using lower doses in elderly patients. Diazepam is a water-insolu- ble drug that is dissolved in the organic solvent propylene glycol that causes pain on intravenous or intramuscular injection. Diazepam is metabolized by the liver into two active metabolites, desmethyldiazepam, and oxazepam. The activity of these metabolites may cause prolonged sedation for 2–4 days in elderly patients and in those with impaired liver function. Lorazepam is an inter- mediate-acting benzodiazepine with a stronger amnestic effect and a delayed peak effect, making it the least favored benzodiazepine for procedural sedation (Table 5.2).
Flumazenil is the only known benzodiazepine antagonist. A dose of 0.2 mg IV every 1 min to a total dose of 1–3 mg/1 h is commonly used. The onset of action is at 1–3 min, the peak is at 10 min, and the duration of action is 20 min. Additional doses may be required to maintain antagonism and prevent the recurrence of seda-
Table 5.2 Pharmacodynamics of benzodiazepines
Drug |
Dose (mg/kg) |
Elimination half-life (h) |
Midazolam |
0.3–0.5 |
1–4 |
|
|
|
Lorazepam |
0.05 |
10–20 |
|
|
|
Diazepam |
0.15–0.3 |
21–37 |
Table 5.3 Pharmacodynamics of commonly used opioids
tion by longer-acting benzodiazepines. Side effects of fumazenil include nausea, vomiting, tachycardia, hypertension, headache, and rarely seizures.
Opioids: These are natural and synthetic substances that bind opioid receptors in the central nervous system and peripheral tissue, causing presynaptic inhibition of release of neurotransmitters (e.g., acetylcholine, dopamine, norepinephrine, and substance P). Activation of the opioid receptors mu, kappa, and delta results in varying degrees of analgesia and side effects such as depression of ventilation, urinary retention, constipation, miosis, and physical dependence. The naturally occurring opioid morphine and the synthetic opioids meperidine, fentanyl, sufentanil, alfentanil, and remifentanil have been used for bronchoscopic procedural sedation. Fentanyl is the most commonly used opioid for bronchoscopy sedation due to its rapid onset of action and short half-life. Although therapeutic bronchoscopy is not associated with signi cant somatic pain, opioids were found to cause suppression of airway refexes in particular cough, tachycardia, and hypertension associated with bronchoscopy [16]. See Table 5.3 for a comparison between the pharmacodynamics of different opioids. Noteworthy is that the combination of opioids and benzodiazepines is associated with better patient’s tolerance of bronchoscopy when compared to each agent alone [17].
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Context-sensitive |
|
|
Onset (min) |
Peak (min) |
Duration (h) |
Elimination (h) |
half-life (min) |
Potency |
Morphine |
2–3 |
15–30 |
3 h |
2–3 |
|
1 |
Meperidine |
5 |
5–7 |
3 h |
3–5 |
|
0.1 |
|
|
|
|
|
|
|
Fentanyl |
1–2 |
3–5 |
0.5–1 |
3–6 |
260 |
75–125 |
|
|
|
|
|
|
|
Sufentanil |
1–2 |
3–5 |
0.3 |
2–4 |
30 |
500–1000 |
|
|
|
|
|
|
|
Alfentanyl |
1–2 |
1.5–2 |
0.2–0.3 |
1.4–1.5 |
60 |
10–25 |
Remifentanyl |
1–2 |
1.5–2 |
0.1–0.2 |
0.17–0.33 |
4 |
250 |
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